Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies

Perspectives of Mesenchymal Stem Cell-Based Neuroregeneration

Stem cell-based therapy seems to be a promising strategy to treat neurodegenerative diseases, in particular those that are fatal and difficult to treat. However, the sources of stem cells are required to comply with the requirement of availability and expanding in culture, to overcome ethical objections and concerns of graft rejection. Mesenchymal stem cells (MSCs) are population of adult stem ...

Advances in Stem Cell Therapies

Potential use of Dental Pulp Stem Cell in Laboratory Studies and Clinical Trials

Stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type I diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. In addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

Dental pulp as a stem cell reservoir.

Currently, much information is provided regarding the presence and the roles in tissue regeneration of stem cell niches residing in post-natal dental pulp. So far, three types of adult stem cells have been isolated from dental pulp. Correct evaluation of these cells is important in order to determine their potential use in clinical fields. The present study aims to review the origins and immuno...

Advances in Hematopoietic Stem Cell Mobilization and Peripheral Blood Stem Cell Transplantation

Hematopoietic stem/progenitor cells (HSPCs) which give rise to different blood cell types are present within the bone marrow microenvironment, especially in flat bones such as skull, vertebrae, pelvis and chest. Interacting factors such as stromal derived factor-1/CXCR4, very late antigen-4/vascular cell adhesion molecule-1, Lymphocyte function-associated antigen-1/ intercellular adhesion molec...